Reference of 147127-20-6, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 147127-20-6, Name is Tenofovir, SMILES is [C@H](OC[P](=O)(O)O)(C[N]1C2=C(N=C1)C(=NC=N2)N)C, belongs to indole-building-block compound. In a article, author is Shi, Xiaolin, introduce new discover of the category.
Cu(II)-Catalyzed Oxidative Trifluoromethylation of Indoles with KF as the Base
This paper offers an efficient copper-catalyzed oxidative trifluoromethylation of indoles with low-cost CF3SO2Na via C-H activation. Notably, the use of a base is crucial for the trifluoromethylation of indoles. This reaction proceeds efficiently in good to excellent yields and is tolerance of a broad range of functional groups. Furthermore, melatonin, a medicine for sleep disorders, is converted to its 2-CF3 analogue in 68% yield. Studies of possible reaction pathways suggest that this reaction proceeds through a radical process.
Reference of 147127-20-6, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 147127-20-6 is helpful to your research.
Reference:
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles