Related Products of 26807-73-8, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 26807-73-8, Name is 1-Benzyl-1H-indol-5-amine, molecular formula is C15H14N2. In a Article£¬once mentioned of 26807-73-8
Synthesis and Dopamine Agonist Properties of (+/-)-trans-3,4,4a,10b-Tetrahydro-4-propyl-2H,5H-<1>benzopyrano<4,3-b>-1,4-oxazin-9-ol and Its Enantiomers
The dopamine agonist profile of (+/-)-trans-3,4,4a,10b-tetrahydro-4-propyl-2H,5H-<1>benzopyrano<4,3-b>-1,4-oxazin-9-ol (16a) and its enantiomers (16b-c) was examined.Racemic 16a exhibited moderate affinity for the dopamine (DA) D2 receptor labeled with the DA antagonist ligand <3H>haloperidol and moderate in vivo activity; it attenuated gamma-butyrolactone-stimulated DA synthesis, decreased DA neuronal firing of substantia nigra DA neurons, and inhibited exploratory locomotor activity in rats, a profile consistent with a DA autoreceptor agonist mechanism of action.The (+)-enantiomer 16b possessed greater DA receptor affinity with the agonist ligand <3H>-N-propylnorapomorphine then with the antagonist ligand.In rats it potently inhibited DA synthesis and neuronal firing and also inhibited exploratory locomotion.The (-)-enantiomer, on the other hand, did not have significant activity in any of these tests.This profile indicates that like many other rigid DA agonists, the dopaminergic activity resides in one enantiomer, in this case the (+)-enantiomer 16b.On the basis of single-crystal X-ray analysis of a key intermediate, the absolute configuration of 16b was found to be 4aR, 10bR.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Related Products of 26807-73-8, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 26807-73-8, in my other articles.
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Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles