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In this communication, we report a substrate-controlled product diversity in the 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD)-catalyzed cascade cyclization of 2-alkynyl-3,3-difluoro-3H-indoles with N, N- or N, S-bis-nucleophiles. The products represent two important heterocyclic compounds, C2-spiro indoline, and pyrimido[1,2-a] benzimidazole, featuring a versatile gem-difluoromethylene group on the framework. In these cascade processes, two new C-N bonds, or one C-S and one C-N bond, are consecutively formed in a single step. The present protocol is characterized with high regioselectivity, high yield, broad substrate scope, good functional group tolerance, facile scalability and mild reaction conditions.
I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 303-38-8 help many people in the next few years. Computed Properties of https://www.ambeed.com/products/303-38-8.html.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles