Computed Properties of C8H8O2. In 2020.0 ANGEW CHEM INT EDIT published article about SELECTIVE BIOCONJUGATION; ALKYLATION; PROTEINS in [Tobiesen, Henriette N.; Leth, Lars A.; Iversen, Marc V.; Naesborg, Line; Jorgensen, Karl Anker] Aarhus Univ, Dept Chem, DK-8000 Aarhus C, Denmark; [Tobiesen, Henriette N.; Bertelsen, Soren] Novo Nordisk AS, Global Res Technol, Res Chem, DK-2760 Malov, Denmark in 2020.0, Cited 36.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4.
The first stereoselective, near-equimolar, and metal-free oxidative bioconjugation of amino acids and oligopeptides to aldehydes is presented. Based on a newly developed organocatalytic oxidative concept, the C-terminal and side-chain carboxylic acid functionalities of amino acids and oligopeptides are shown to couple in a stereoselective manner to alpha-branched aldehydes catalyzed by a chiral primary amine and a quinone as oxidizing agent. The oxidative coupling generally proceeds in high yield. For aspartic acid, selective coupling of the side-chain, or the C-terminal carboxylic acid, is demonstrated depending on the protection strategy. The stereoselective, oxidative bioconjugation concept is extended to a series of oligopeptides where coupling to carboxylic acid functionalities is presented. Bioorthogonal linker molecules for further functionalization are obtained by merging the oxidative coupling strategy with the click concept. It is demonstrated that the configuration of the new stereocenter is determined exclusively by the organocatalyst.
Computed Properties of C8H8O2. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Tobiesen, HN; Leth, LA; Iversen, MV; Naesborg, L; Bertelsen, S; Jorgensen, KA or concate me.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles