Safety of 4′-Hydroxyacetophenone. In 2021.0 J BRAZIL CHEM SOC published article about MICROWAVE-ASSISTED SYNTHESIS; ONE-POT SYNTHESIS; 1,5-BENZODIAZEPINE DERIVATIVES; BIOLOGICAL EVALUATION; EFFICIENT SYNTHESIS; DESIGN; BENZODIAZEPINES; CHEMISTRY; AGENTS in [Caiana, Elizeu C.; de Souza, Antonia L.; Queiroz, Neide] Univ Fed Paraiba, Dept Quim, BR-58051900 Joao Pessoa, PB, Brazil; [de Veras, Bruno O.] Univ Fed Pernambuco, Dept Med Trop, BR-50670901 Recife, PE, Brazil in 2021.0, Cited 48.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4.
Benzodiazepines derivatives are nitrogen heterocyclic compounds that have various industrial, synthetic, and medicinal applications. Therefore, its potential fully justifies every effort towards the improvement of new, selective, and competent production of these heterocyclic compounds. The novelty of this study encompasses the synthesis of new hydroxylated analogs of 1,5-benzodiazepine together with the evaluation of their biological potential as antioxidants and antifungals candidates. Additionally, the reported antifungal activity against fungi of the Sporothrix schenckii complex inaugurates an unprecedented property for this class of compounds. The results of biological activities assays suggest that the novel 2,7-dimethyl-2,4-bis(4-hydroxyphenyl)-2,3-dihydro1H-1,5-benzodiazepine possesses a high antifungal activity against all fungal strains evaluated of the Sporothrix genus and outstanding total antioxidant capacity. Besides, in silico studies have evidenced that the hydroxylated derivatives have the best aqueous solubility and cell permeability profile, which makes them superior in comparison with the commercial antifungal itraconazole, a drug commonly used in the treatment of sporotrichosis.
Welcome to talk about 99-93-4, If you have any questions, you can contact Caiana, EC; de Veras, BO; de Souza, AL; Queiroz, N or send Email.. Safety of 4′-Hydroxyacetophenone
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles