Chemistry, like all the natural sciences, Category: indole-building-block, begins with the direct observation of nature— in this case, of matter.156-38-7, Name is 4-Hydroxyphenylacetic Acid, SMILES is OC(=O)CC1=CC=C(O)C=C1, belongs to indole-building-block compound. In a document, author is Liu, Jianming, introduce the new discover.
An intermolecular [2+3+1] annulation between indole and 2-bromobenzylaldehyde derivatives was successfully achieved by utilizing elemental sulfur as the promoter and coupling partner. This direct and operationally simple procedure provided a rapid and reliable approach to synthesize functionalized thiochromeno[2,3-b]indoles. Preliminary mechanistic studies indicated that elemental sulfur enhanced the nucleophilicity of the 3-position of indole to attack an aldehyde group, and C-H cleavage of indole was not involved in the rate-determining step.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 156-38-7. Category: indole-building-block.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles