A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 4674-50-4, Name is Nootkatone, molecular formula is C15H22O. In an article, author is Prochnow, Thais,once mentioned of 4674-50-4, Safety of Nootkatone.
Synthesis of 3-(Organochalcogen) Chalcogenazolo Indoles via Cascade Cyclization of N-Alkynylindoles
A transition metal-free one-pot, three-steps protocol combining N-alkynylindoles, n-butyllithium, elemental selenium, and an electrophile source was developed to allow the synthesis of 3-(organoselanyl) selenazolo indoles. Substrate scope was studied by varying the structure of N-alkynylindoles and the electrophile source. This sequential reaction proceeded selectively through an initial intramolecular 5-endo-dig mode with two new carbon selenium bonds formation in a one-pot procedure. The reaction conditions were also compatible with elemental sulfur and tellurium, which led to construct 3-(alkylthio) thiazolo indoles and 3-(alkyltelluro) tellurazolo indoles, respectively. In addition, it was also demonstrated that a series of dichalcogenides derived from chalcogenazoloindoles ring could be easily prepared via oxidation of chalcogenolate anion in contact with air.
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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles