Related Products of 699-83-2, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 699-83-2, Name is 1-(2,6-Dihydroxyphenyl)ethanone, SMILES is CC(C1=C(O)C=CC=C1O)=O, belongs to indole-building-block compound. In a article, author is Padmaja, Pannala, introduce new discover of the category.
A Green Approach to the Synthesis of Novel Indole Substituted 2-Amino-4,5-dihydro-3-furancarbonitriles in Water
2-Amino-4,5-dihydro-3-furancarbonitriles (ADFCs) have attracted much attention due to their utility as valuable synthetic intermediates for the preparation of a series of acyclic and cyclic organic compounds. On the other hand, indoles substituted with furans are highly interesting compounds displaying a wide range of biological and pharmaceutical activities. However, to the best of our knowledge, indole substituted 2-amino-4,5-dihydro-3-furancarbonitriles have not been previously reported. A new and efficient synthesis of indole substituted 2-amino-4,5-dihydro-3-furancarbonitriles has been developed in two steps using water as a solvent. The first step of the sequence involves three-component reaction of phenylglyoxals, indoles and malononitrile under aqueous and catalyst-free conditions for the synthesis of indole substituted beta,beta-dicyanoketones. Reduction of the obtained beta,beta-dicyanoketones with sodium borohydride in water at room temperature afforded the indole substituted 2-amino-4,5-dihydro-3-furancarbonitriles in good yields. Several substituted phenylglyooxals were reacted smoothly with indole or 2-methylindole and malononitrile to give the corresponding indole substituted beta,beta-dicyanoketones in good yields. Treatment of the obtained beta,beta-dicyanoketones with sodium borohydride in water furnished exclusively the indole substituted 2-amino-4,5-dihydro-3-furancarbonitriles in good yields. We have developed an efficient straightforward access to indole substituted beta,beta-dicyanoketones by one-pot three-component reaction of phenylglyoxals, indoles and malononitrile. The synthetic utility of obtained indole substituted beta,beta-dicyanoketones has been outlined by the preparation of indole substituted 2-amino-4,5-dihydro-3-furancarbonitriles. The advantage of catalyst-free, atom-economical and environmental benignity render it promising methods for preparation of indole substituted 2-amino-4,5-dihydro-3-furancarbonitriles.
Related Products of 699-83-2, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 699-83-2 is helpful to your research.
Reference:
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles