Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 732-26-3, Name is 2,4,6-Tri-tert-butylphenol, SMILES is OC1=C(C(C)(C)C)C=C(C(C)(C)C)C=C1C(C)(C)C, in an article , author is Hua, Yanan, once mentioned of 732-26-3, SDS of cas: 732-26-3.
Isatin inhibits the invasion and metastasis of SH-SY5Y neuroblastoma cells in vitro and in vivo
Indoline-2,3-dione or indole-1H-2,3-dione, commonly known as isatin, is found in plants of genus Isatin and in Couropita guianancis aubl, and inhibits tumor cell proliferation through its antioxidant effects. The present study analyzed the effect of isatin on the malignant phenotype of neuroblastoma cells, and reported that isatin significantly inhibited neuroblastoma cell proliferation, invasion and migration in vitro in a dose-dependent manner, and distant metastasis in tumor-bearing mice. Mechanistically, isatin inhibited lysine-specific histone demethylase (LSD)1 and reversed the blockade on p53, thereby activating the apoptotic pathway. The inhibitory effect of isatin on LSD1 may be mediated via direct binding and molecular docking or indirectly through the TGF beta/ERK/NF-kappa B signaling pathway. Isatin also alleviated the renal and hepatic toxicity of cyclophosphamide in the tumor-bearing mice, indicating its potential as a candidate drug as well as an adjuvant for treating metastatic neuroblastoma.
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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles