Application of 342573-75-5, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, 342573-75-5, Name is 1-Ethyl-3-methylimidazolium ethylsulfate, SMILES is C[N+]1=CN(CC)C=C1.O=S(OCC)([O-])=O, belongs to indole-building-block compound. In a article, author is Liu, Kai, introduce new discover of the category.
Through a structure-based molecular hybridization strategy, a series of newN-acylhydrazone derivatives containing the benzothiazole and indole based moiety were designed, synthesized and screened forin vitroantiproliferative activity against Hep G2 cancer cell line. One compound (7a) exhibited excellent antiproliferative activity with IC(50)values of 0.78 mu M against Hep G2. In addition, C-5 substitutions of the indole ring of target compounds might be crucial for their cytotoxic activities. Additionally, the relative configuration of target compounds was confirmed as theEisomer. Further chemical manipulation of derivative 7a can make it possible to obtain new potential antitumor agents.
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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles