The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 156-38-7, Name is 4-Hydroxyphenylacetic Acid, SMILES is OC(=O)CC1=CC=C(O)C=C1, in an article , author is Goericke, Fabian, once mentioned of 156-38-7, HPLC of Formula: C8H8O3.
Palladium-Catalyzed, Enantioselective (3+2)-Cycloannulation of beta-Keto Esters with Alkylidene 2H-Indoles toward Complex Indole-Based Heterocycles
A cooperative approach toward biologically important N-fused polycyclic indoles with synthetically challenging tetracyclic [6-5-5-6] and [6-5-5-5] core structures has been developed. The concept is based on a highly stereoselective (3 + 2)-cycloannulation of chiral metal enolates with a reactive vinylogous iminium ion, both generated in situ via dual activation with a single chiral Pd catalyst (5 mol %). Densely functionalized pyrrolo[1,2-a]indoles with three contiguous chiral centers were constructed with high stereoselectivities (>95:5 d.r. and up to >99% ee) and excellent yields (up to 99%). ESI-MS studies and additional control experiments provided a clear mechanistic picture of the cycloannulation event. The products were readily transformed into an array of valuable, indole-based, highly complex heterocycles.
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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles