A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, COA of Formula: C11H10N2O4, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 6960-46-9, Name is Ethyl 7-nitro-1H-indole-2-carboxylate, molecular formula is C11H10N2O4. In a Article, authors is Xiong, Li£¬once mentioned of 6960-46-9
Discovery of Potent Succinate-Ubiquinone Oxidoreductase Inhibitors via Pharmacophore-linked Fragment Virtual Screening Approach
Succinate-ubiquinone oxidoreductase (SQR) is an attractive target for fungicide discovery. Herein, we report the discovery of novel SQR inhibitors using a pharmacophore-linked fragment virtual screening approach, a new drug design method developed in our laboratory. Among newly designed compounds, compound 9s was identified as the most potent inhibitor with a Ki value of 34 nM against porcine SQR, displaying approximately 10-fold higher potency than that of the commercial control penthiopyrad. Further inhibitory kinetics studies revealed that compound 9s is a noncompetitive inhibitor with respect to the substrate cytochrome c and DCIP. Interestingly, compounds 8a, 9h, 9j, and 9k exhibited good in vivo preventive effects against Rhizoctonia solani. The results obtained from molecular modeling showed that the orientation of the R2 group had a significant effect on binding with the protein.
I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 6960-46-9, help many people in the next few years.COA of Formula: C11H10N2O4
Reference£º
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles