Daily Rhythm in Plasma N-acetyltryptamine was written by Backlund, Peter S.;Urbanski, Henryk F.;Doll, Mark A.;Hein, David W.;Bozinoski, Marjan;Mason, Christopher E.;Coon, Steven L.;Klein, David C.. And the article was included in Journal of Biological Rhythms in 2017.Quality Control of N-(2-(1H-Indol-3-yl)ethyl)acetamide This article mentions the following:
Normal physiol. undergoes 24-h changes in function that include daily rhythms in circulating hormones, most notably melatonin and cortical steroids. This study focused on N-acetyltryptamine, a little-studied melatonin receptor mixed agonist-antagonist and the likely evolutionary precursor of melatonin. The central issue addressed was whether N-acetyltryptamine is physiol. present in the circulation. N-acetyltryptamine was detected by LC-MS/MS in daytime plasma of 3 different mammals in subnanomolar levels (mean 卤 SEM: rat, 0.29 卤 0.05 nM, n = 5; rhesus macaque, 0.54 卤 0.24 nM, n = 4; human, 0.03 卤 0.01 nM, n = 32). Anal. of 24-h blood collections from rhesus macaques revealed a nocturnal increase in plasma N-acetyltryptamine (p < 0.001), which varied from 2- to 15-fold over daytime levels among the 4 animals studied. Related RNA sequencing studies indicated that the transcript encoding the tryptamine acetylating enzyme arylalkylamine N-acetyltransferase (AANAT) is expressed at similar levels in the rhesus pineal gland and retina, thereby indicating that either tissue could contribute to circulating N-acetyltryptamine. The evidence that N-acetyltryptamine is a physiol. component of mammalian blood and exhibits a daily rhythm, together with known effects as a melatonin receptor mixed agonist-antagonist, shifts the status of N-acetyltryptamine from pharmacol. tool to candidate for a physiol. role. This provides a new opportunity to extend our understanding of 24-h biol. In the experiment, the researchers used many compounds, for example, N-(2-(1H-Indol-3-yl)ethyl)acetamide (cas: 1016-47-3Quality Control of N-(2-(1H-Indol-3-yl)ethyl)acetamide).
N-(2-(1H-Indol-3-yl)ethyl)acetamide (cas: 1016-47-3) belongs to indole derivatives. In addition to tryptophan, indigo, and indoleacetic acid, numerous compounds obtainable from plant or animal sources contain the indole molecular structure. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.Quality Control of N-(2-(1H-Indol-3-yl)ethyl)acetamide
Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles