Cu(I)-catalyzed intramolecular cyclization of ene-carbamates: synthesis of indoles and pyrrolo[2,3-c]pyridines was written by Barberis, Claude;Gordon, Thomas D.;Thomas, Christine;Zhang, Xiaolei;Cusack, Kevin P.. And the article was included in Tetrahedron Letters in 2005.Name: Methyl 5-fluoro-1H-indole-2-carboxylate This article mentions the following:
Over the past few years, the use of palladium-catalyzed aromatic carbon-nitrogen bond forming reactions by the cross-coupling of aryl halides or triflates and amines has become a useful synthetic tool. Herein, a copper(I) catalyst system that allows efficient synthesis of functionalized indoles and pyrrolo[2,3-c]pyridine derivatives was described. This method takes advantage of amino acid promoted copper coupling of amines with aryl halides, in particular, the use of the CuI/L-proline catalyst system. In the experiment, the researchers used many compounds, for example, Methyl 5-fluoro-1H-indole-2-carboxylate (cas: 167631-84-7Name: Methyl 5-fluoro-1H-indole-2-carboxylate).
Methyl 5-fluoro-1H-indole-2-carboxylate (cas: 167631-84-7) belongs to indole derivatives. Indole could be stereoselectively alkylated with chiral cyclopentyl sulfone reagent. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Name: Methyl 5-fluoro-1H-indole-2-carboxylate
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Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles