The effect of chloro-derivatives of indoleacetic acid on plasma membrane electron transport and proton excretion was written by Barr, Rita;Boettger, Michael;Crane, Frederick L.. And the article was included in Proceedings of the Indiana Academy of Science in 1991.Synthetic Route of C10H8ClNO2 This article mentions the following:
As shown by M. Boettger and H. Hilgendorf (1988), the natural auxin indoleacetic acid in high concentrations (10 濠电偞鎸鹃幏? inhibited both e– and proton efflux by corn roots of undamaged plants measured with a pH-stat combined with a redoxstat. In this study, it is shown that of various chloro-substituted indoleacetic acid derivatives, only 4-chloro-IAA inhibited NADH oxidation and several derivatives stimulated trans-membrane hexacyanoferrate reduction in concentrations from 0.1 nM to 10 濠电偞鎸鹃幏?in cultured carrot cells. Proton excretion by these cells was also stimulated by 5-, 6- and 5,7-chloro substituted indoleacetic acid, but the 4-chloro derivative inhibited H+ excretion by the plasma membrane H+-ATPase, while H+ excretion in presence of hexacyanoferrate was stimulated. These divergent effects of chloro-substituted indoleacetic acid derivatives show that the trans-membrane redox system is not directly related to proton movement through the membrane in a 1:1 relationship. In the experiment, the researchers used many compounds, for example, 2-(5-Chloro-1H-indol-3-yl)acetic acid (cas: 1912-45-4Synthetic Route of C10H8ClNO2).
2-(5-Chloro-1H-indol-3-yl)acetic acid (cas: 1912-45-4) belongs to indole derivatives. Indole exists overwhelmingly in the 1H-indole form as do other simple indoles. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Synthetic Route of C10H8ClNO2
Referemce:
Indole alkaloid derivatives as building blocks of natural products from闂佽壈浜崹淇沜illus thuringiensis闂佽壈浜粋鍧闂佽壈浜崹淇沜illus velezensis闂佽壈浜粋鍧 their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles