Synthesis of 1-(3-aminopropyl)indoles and 3-indol-1-ylpropionic acids was written by Basanagoudar, L. D.;Siddappa, S.. And the article was included in Journal of the Chemical Society [Section] C: Organic in 1967.Synthetic Route of C11H11NO2 This article mentions the following:
Various substituted indoles and their derivatives were condensed with acrylonitrile in the presence of trimethylbenzylammonium hydroxide to give the corresponding 3-indol-1-ylpropionitriles. These nitriles were reduced catalytically with Raney nickel to the corresponding 1-(3-aminopropyl)indoles, or hydrolyzed to the corresponding 3-indol-1-ylpropionic acids. Some of the nitriles were formylated to give the corresponding 1-(2-cyanoethyl)indole-3-carboxaldehydes. In the experiment, the researchers used many compounds, for example, 3-(1H-Indol-1-yl)propanoic acid (cas: 6639-06-1Synthetic Route of C11H11NO2).
3-(1H-Indol-1-yl)propanoic acid (cas: 6639-06-1) belongs to indole derivatives. The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades. In addition to indole, the strain-release chemistry worked for numerous substrates including amines, alcohols, thiols, carboxylic acids, imidazoles, and pyrazoles.Synthetic Route of C11H11NO2
Referemce:
Indole alkaloid derivatives as building blocks of natural products from闂佽壈浜崹淇沜illus thuringiensis闂佽壈浜粋鍧闂佽壈浜崹淇沜illus velezensis闂佽壈浜粋鍧 their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles