Functionalisation of isoindolinones via a calcium catalysed Hosomi-Sakurai allylation was written by Basson, Ashley J.;McLaughlin, Mark G.. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2019.Category: indole-building-block This article mentions the following:
A rapid and functionally tolerant calcium catalyzed Hosomi-Sakurai reaction has been realized. Employing 1 mol% calcium, allylated isoindolinones I (R1 = H, C6H5, 4-F3CC6H4, thien-2-yl, 1H-benzodioxol-5-yl, etc.; R2 = H, Me, allyl, benzyl; R3 = H, CH3, 4-BrC6H4) can be synthesized in high yields and the reaction is shown to be tolerant to a range of medicinally relevant functional groups including heterocycles. The synthetic utility of the reaction has been shown, and a plausible reaction mechanism is provided. In the experiment, the researchers used many compounds, for example, 2-Allylisoindoline-1,3-dione (cas: 5428-09-1Category: indole-building-block).
2-Allylisoindoline-1,3-dione (cas: 5428-09-1) belongs to indole derivatives. Indole exists overwhelmingly in the 1H-indole form as do other simple indoles.Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.Category: indole-building-block
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Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles