On November 30, 1977, Bergman, Jan; Carlsson, Rene; Sjoberg, Birger published an article.Safety of Methyl 2-methyl-1H-indole-3-carboxylate The title of the article was The reaction of indole and the indole Grignard reagent with phosgene. A facile synthesis of indole-3-carboxylic acid derivatives. And the article contained the following:
Indole-3-carboxylic and indole-3-glyoxylic acid derivatives were prepared from indoles or oxindoles and phosgene or oxalyl chloride. In this reaction, the indole Grignard reagent gave several products, including the cyclotetramers I (X = CO, COCO). Indolo-fused heterocycles were also prepared by this reaction. Thus, phosgene and 2-(2-hydroxyphenyl)-N-methylindole gave 5,6-dihydro-11-methyl-6-oxobenzo[a]pyrano[4,3-b]indole (II). The experimental process involved the reaction of Methyl 2-methyl-1H-indole-3-carboxylate(cas: 65417-22-3).Safety of Methyl 2-methyl-1H-indole-3-carboxylate
The Article related to indole reaction phosgene, oxindole reaction phosgene, oxalyl chloride reaction indole, grignard indole phosgene, benzopyranoindole, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Safety of Methyl 2-methyl-1H-indole-3-carboxylate
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles