Nucleophilic substitution of aromatic radicals. A new synthesis of the indole skeleton was written by Beugelmans, Rene;Roussi, Georges. And the article was included in Tetrahedron, Supplement in 1981.Quality Control of 2-Methyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole This article mentions the following:
Photochem. nucleophilic substitution reactions of 2-IC6H4NH2 with aliphatic ketone enolates, aldehyde enolates, and cyclic and heterocyclic enolates, gave indole derivatives (20-85%). E.g., 2-IC6H4NH2 with MeC(OK):CH2 (irradiation, liquid NH3, 16 min) gave 83% I. Ketone enolates gave 2-substituted indoles whereas aldehyde enolates gave 3-substituted products; cyclic enolates gave tricyclic indoles. The reaction occurs by an SRN1 process. In the experiment, the researchers used many compounds, for example, 2-Methyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole (cas: 5094-12-2Quality Control of 2-Methyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole).
2-Methyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole (cas: 5094-12-2) belongs to indole derivatives. Indole produced by Proteus, Pseudomonas, Escherichia and other species was shown to be a growth promoting factor in Arabidopsis thaliana. Due to this activity, the indole ring system has become an important component or intermediate in the synthesis of heterocycles.Quality Control of 2-Methyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole
Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles