Bisag, Giorgiana Denisa; Pecorari, Daniel; Mazzanti, Andrea; Bernardi, Luca; Fochi, Mariafrancesca; Bencivenni, Giorgio; Bertuzzi, Giulio; Corti, Vasco published the artcile< Central-to-Axial Chirality Conversion Approach Designed on Organocatalytic Enantioselective Povarov Cycloadditions: First Access to Configurationally Stable Indole-Quinoline Atropisomers>, Name: 4-Methyl-1H-indole-3-carbaldehyde, the main research area is chiral indole quinoline preparation; alkenylindole arylimine enantioselective Povarov cycloaddition axial chirality organocatalyst; Povarov cycloaddition; atropisomerism; chirality; indoles; quinolines.
The first stereoselective synthesis of enantioenriched axially chiral indole-quinoline systems is presented. The strategy takes advantage of an organocatalytic enantioselective Povarov cycloaddition of 3-alkenylindoles and N-arylimines, followed by an oxidative central-to-axial chirality conversion process, allowing for access to previously unreported axially chiral indole-quinoline biaryls. The methodol. is also implemented for the design and the preparation of challenging compounds exhibiting two stereogenic axes. DFT calculations shed light on the stereoselectivity of the central-to-axial chirality conversion, showing unconventional behavior.
Chemistry – A European Journal published new progress about Aromatic imines Role: RCT (Reactant), RACT (Reactant or Reagent). 4771-48-6 belongs to class indole-building-block, and the molecular formula is C10H9NO, Name: 4-Methyl-1H-indole-3-carbaldehyde.
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles