Blackburn, Chester; Tai, Hongyun; Salerno, Martina; Wang, Xi; Hartsuiker, Edgar; Wang, Wenxin published the artcile< Folic acid and rhodamine labelled pH responsive hyperbranched polymers: Synthesis, characterization and cell uptake studies>, Computed Properties of 950846-89-6, the main research area is folic acid rhodamine labeled hyperbranched polymer cell uptake pH.
Here, we report the synthesis of novel folated and fluorescent labeled pH responsive hyperbranched polymers (HBPs) via reversible addition fragmentation chain-transfer (RAFT) co-polymerization of 2-Pr acrylic acid (PAA), 2-(dimethylamino) Et methacrylate (DMAEMA) and disulfide diacrylate (DSDA) using 4-cyano-4-(((dodecylthio)carbonothioyl)thio)pentanoic acid (CDCTPA) as RAFT agent and post functionalization via bioconjugation techniques. The resultant HBPs were characterized by NMR Spectroscopy (NMR) and Size Exclusion Chromatog. (SEC). Dynamic Light Scattering (DLS) technique was used to measure the size changes of HPBs in solutions at different pH values to demonstrate pH responsiveness of the polymers. The cell uptake evaluations on these folated and fluorescent labeled HBPs were carried out using HeLa cell line and confirmed by confocal images. The results show that we have successfully synthesized the desired multifunctional hyperbranched poly (PAA-co-DMAEMA-co-DSDA) with a pH responsive characteristic and the potentials for use as a drug delivery vehicle.
European Polymer Journal published new progress about Biological uptake. 950846-89-6 belongs to class indole-building-block, and the molecular formula is C30H36N4O2, Computed Properties of 950846-89-6.
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Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles