Synthesis and characterization of new indole derivatives for analgesic activity was written by Blessi, Priyanka K.;Maharaj, Pogula;Suresh, S.;Thirupathi, K.;Sammaiah, G.. And the article was included in International Journal of Pharmacy and Pharmaceutical Sciences in 2012.Product Details of 112656-95-8 This article mentions the following:
A series of indole derivatives I(R =H, 7-Cl, 5-Cl, 5-Br, 5-CO2H, 5-Me, 5-NO2, 7-NO2, 7-CO2Me) were prepared and profiled as antipyretic compounds All the synthesized derivatives were characterized by chromatog., IR, 1H NMR and MASS spectral anal. The synthesized derivatives were evaluated for in vivo analgesic activity by using Diclofenac sodium as a standard Prepared compound (R = 5-NO2) showed potent activity when compared to Diclofenac sodium. In the experiment, the researchers used many compounds, for example, 7-Nitroindoline-2,3-dione (cas: 112656-95-8Product Details of 112656-95-8).
7-Nitroindoline-2,3-dione (cas: 112656-95-8) belongs to indole derivatives. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. Moreover, it is known that it controls biofilm formation. However, the role of indole in the cell has not been fully elucidated.Product Details of 112656-95-8
Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles