Effect of selection of QTc formula on eligibility of cancer patients for phase I clinical trials was written by Borad, Mitesh J.;Soman, Arundhati D.;Benjamin, Martin;Casa, Daniel;Tembe, Waibhav D.;Piper, Barbara F.;Ramanathan, Ramesh;Tibes, Raoul;Jameson, Gayle;Ansaldo, Karen;Hoff, Daniel D.. And the article was included in Investigational New Drugs in 2013.Computed Properties of C19H20N2O3 This article mentions the following:
A retrospective anal. of 130 patients was conducted in a Phase I oncol. clinic to assess the effect of QTc formula selection on clin. trial eligibility. QTc values were calculated from screening electrocardiograms using 7 formulas (Bazett, Fridericia, Framingham, Hodges, Mayeda, Van de Water and Wohlfart). QTc values>470 ms for females and>450 ms for males were used to define prolongation. Concomitant medication potential for QTc prolongation was determined using a public database (AzCert). Ineligibility rates ranged from 3.1 % to 17.7 % (Framingham: 3.1 %, Van de Water: 3.1 %, Hodges: 3.1 %, Wohlfart: 3.1 %, Fridericia: 3.9 %, Bazett: 10.8 % and Mayeda: 17.7 %). A consistent ineligibility rate was achieved by using formulas-specific thresholds. Fifty one percent of patients were taking concomitant medications with QTc prolongation potential. The proportion of concomitant medications with the potential to prolong QTc was 11.57 % (96 of 830). Uniform criteria and guidelines for selection of QTc formulas need to be developed. Formulas-specific QTc thresholds also need to be specified. In the experiment, the researchers used many compounds, for example, rel-(5s,6R,8r,9aS)-3-Oxooctahydro-1H-2,6-methanoquinolizin-8-yl 1H-indole-3-carboxylate (cas: 115956-12-2Computed Properties of C19H20N2O3).
rel-(5s,6R,8r,9aS)-3-Oxooctahydro-1H-2,6-methanoquinolizin-8-yl 1H-indole-3-carboxylate (cas: 115956-12-2) belongs to indole derivatives. In addition to tryptophan, indigo, and indoleacetic acid, numerous compounds obtainable from plant or animal sources contain the indole molecular structure. They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.Computed Properties of C19H20N2O3
Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles