《Synthesis and crystal structures of fluorinated indoles as RNA analogues》 was published in Collection Symposium Series in 2005. These research results belong to Bozilovic, Jelena; Bats, Jan W.; Engels, Joachim W.. Category: indole-building-block The article mentions the following:
Fluorinated indole nucleosides I (R1 = H, R2 = F; R1 = R2 = F; R1 = H, R2 = H) have been synthesized as RNA nucleosides. We crystallized two of the synthesized nucleosides. The sugar ring of I (R1 = H, R2 = F) has between a C3′-endo envelope and C2′-exo,C3′-endo half-chair conformation. The sugar ring of I (R1 = R2 = F) has a C3′-endo envelope conformation. Both fluoroindole groups are essentially planar. Neighboring layers of both crystals are connected by C-H···F-C interactions with bond distances of 2,39 and 2.40Å with C-H-F angles of 155°. All the synthesized nucleosides are going to be incorporated in RNA oligonucleotides and UV-melting profiles and CD-spectra are going to be determined The experimental process involved the reaction of Methyl 4-fluoro-1H-indole-2-carboxylate(cas: 113162-36-0Category: indole-building-block)
Methyl 4-fluoro-1H-indole-2-carboxylate(cas: 113162-36-0) is a member of aromaticfluorinated building blocks. Depending on which substituents are present, fluoroaromatic intermediates can be converted into fluorinated or fluorine-free commercial end products.Fluorine-containing aromatics have been incorporated into drugs (hypnotics, tranquilizers, antiinflammatory agents, analgesics, antibacterials).Category: indole-building-block
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles