COA of Formula: C10H8FNO2On September 30, 2007 ,《Synthesis of Fluorinated Indoles as RNA Analogues》 was published in Nucleosides, Nucleotides & Nucleic Acids. The article was written by Bozilovic, Jelena; Engels, Joachim W.. The article contains the following contents:
Nucleoside analogs, e.g. I, are chem. means to investigate hydrogen bonds, base stacking, and solvation as the three predominant forces that are responsible for the stability of secondary structure of nucleic acids. To obtain deeper insight into the contributions of these interactions to RNA stability apart from the ones exerted by the predominant nucleosides we decided to synthesize some novel nucleic acid analogs where the nucleobases are replaced by fluoroindoles. Fluorinated indoles can be compared to fluorinated benzimidazoles to determine the role of nitrogen in five membered ring system. The synthesis of fluoroindole ribonucleosides is described here. In the experiment, the researchers used Methyl 4-fluoro-1H-indole-2-carboxylate(cas: 113162-36-0COA of Formula: C10H8FNO2)
Methyl 4-fluoro-1H-indole-2-carboxylate(cas: 113162-36-0) is a member of aromaticfluorinated building blocks. Depending on which substituents are present, fluoroaromatic intermediates can be converted into fluorinated or fluorine-free commercial end products.Fluorine-containing aromatics have been incorporated into drugs (hypnotics, tranquilizers, antiinflammatory agents, analgesics, antibacterials).COA of Formula: C10H8FNO2
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles