1008-07-7, 7-Chloro-1H-indole-3-carbaldehyde is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A mixture of 7-chloro-1H-indole-3-carboxaldehyde36 (3.6 g, 20 mmol),hydroxylamine hydrochloride (1.40 g, 20 mmol), sodium acetate (1.60 g,20 mmol), glacial acetic acid (63 g, 60 mL) and acetic anhydride (2.2 g,2 mL) was placed in a round bottomed flask and heated under reflux for 4 h. Then the reaction mixture was cooled and poured into ice water. The resulting precipitate was filtered, washed with water, dried and recrystallised from methanol to give the pure product 7-chloro-1H-indole-3-carbonitrile (3.1 g, 88% yield): m.p. 180-182 C. 1H NMR(DMSO-d6, 400 MHz) delta 7.19-7.35 (m, 2H), 7.58-7.64 (m, 1H), 8.32 (d,J = 5.0 Hz, 1H), 12.61 (s, 1H). 13C NMR (DMSO-d6, 100 MHz) delta 113.5,115.7, 118.3, 119.6, 120.1, 122.2, 123.4, 127.9, 137.4. IR (KBr) numax/cm-1 3272, 3124, 2240, 1583, 1441, 1352, 1300, 1211., 1008-07-7
1008-07-7 7-Chloro-1H-indole-3-carbaldehyde 643958, aindole-building-block compound, is more and more widely used in various fields.
Reference：
Article; Wang, Hongshe; Zhao, Weixing; Journal of Chemical Research; vol. 39; 6; (2015); p. 321 – 323;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
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