The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《A chiral interlocking auxiliary strategy for the synthesis of mechanically planar chiral rotaxanes》. Authors are de Juan, Alberto; Lozano, David; Heard, Andrew W.; Jinks, Michael A.; Suarez, Jorge Meijide; Tizzard, Graham J.; Goldup, Stephen M..The article about the compound:1,4-Dibromobutanecas:110-52-1,SMILESS:BrCCCCBr).Application In Synthesis of 1,4-Dibromobutane. Through the article, more information about this compound (cas:110-52-1) is conveyed.
A combination of reaction partners that function as a chiral interlocking auxiliary to both orientate a macrocycle and effectively, load it onto a new axle was discovered. These substrates was used to demonstrate the potential of a chiral interlocking auxiliary strategy for the synthesis of mech. planar chiral rotaxanes by producing a range of examples with high enantiopurity (93-99% e.e.), including so-called ′impossible′ rotaxanes whose axles lack any functional groups that would allow their direct synthesis by other means. Intriguingly, by varying the order of bond-forming steps, can effectively choose which end of an axle the macrocycle is loaded onto, enabling the synthesis of both hands of a single target using the same reactions and building blocks.
In addition to the literature in the link below, there is a lot of literature about this compound(1,4-Dibromobutane)Application In Synthesis of 1,4-Dibromobutane, illustrating the importance and wide applicability of this compound(110-52-1).
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Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles