With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.115666-47-2,6-Iodo-1H-indole,as a common compound, the synthetic route is as follows.
6-Iodo-1H-indole (2, 1.513 g,6.30 mmol, 1.00 equiv, [S2]) was dissolved in CH2Cl2 (90 mL). Boc2O (2.063 g, 9.45 mmol,1.50 equiv) and DMAP (154 mg, 1.26 mmol, 20 mol %) were added and the mixture wasstirred at room temperature overnight. The solvent was evaporated and the crude productwas subjected to column chromatography using petroleum ether/EtOAc (15:1) as the eluentto yield N-Boc-6-iodoindole (3, 2.117 g, 6.17 mmol, 98%) as colorless solid.
115666-47-2, The synthetic route of 115666-47-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Marsch, Nils; Kock, Mario; Lindel, Thomas; Beilstein Journal of Organic Chemistry; vol. 12; (2016); p. 334 – 342;,
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