With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1215-59-4,5-(Benzyloxy)-1H-indole,as a common compound, the synthetic route is as follows.
4.1 To 6.7 g (30 mmol) 5-benzyloxyindole and 6.6 g (30 mmol) di-tert.-butyldicarbonate in 80 ml DMF were added 3.7 g (33 mmol) potassium tert. butylate at RT and the mixture was stirred at 60 C. for 4 h, cooled to RT and ether /0.5 M HC1 were added. The inorganic phase was extracted with ether, the combined organic phases were washed with water and dried over Na2SO4. Evaporation yielded crude 5-Benzyloxy-indole-1-carboxylic acid tert-butyl ester as colorless oil, MS: 323 (M).
The synthetic route of 1215-59-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Ackermann, Jean; Aebi, Johannes; Dehmlow, Henrietta; Morand, Olivier; Panday, Narendra; Weller, Thomas; US2002/103247; (2002); A1;,
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