In an article, author is Ji, Yuan-Zhao, once mentioned the application of 1218-69-5, Quality Control of 2-(2-Hydroxyphenyl)-4H-benzo[e][1,3]oxazin-4-one, Name is 2-(2-Hydroxyphenyl)-4H-benzo[e][1,3]oxazin-4-one, molecular formula is C14H9NO3, molecular weight is 239.23, MDL number is MFCD02234511, category is indole-building-block. Now introduce a scientific discovery about this category.
Switchable regioselection of C-H thiolation of indoles using different TMS counterions
A switchable regioselectivity in C-H thiolation reaction by simply swapping the counteranions of TMS is reported here for the first time. An exclusive C3-H thiolation of indoles with sodium arylsulfinates was achieved in the presence of TMSCl as a promoter. In contrast, with the use of TMSOTf instead of TMSCl under otherwise identical conditions, a regiospecific C2-H thiolation of indoles was realized with the same set of substrates.
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Reference:
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles