1265231-91-1, 3-(Dimethylamino)-2-(1-(phenylsulfonyl)-1H-indole-2-carbonyl)acrylonitrile is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
N-(5-Hydrazinyl-1H-benzo[d]imidazol-2-yl)acetamidedihydrochloride 3d (500mg, 1.8mmol) and 3-(dimethylamino)-2-(1-(phenylsulfonyl)-1H-indole-2-carbonyl)acrylonitrile 1f (477mg, 1.26mmol) were suspended in 20mL of absoluteethanol, the reaction solution was refluxed for 4 hours. The solution was subjected to suction filtration, the filtercake was washed with 5mL of ethanol then the filtrate was concentrated under reduced pressure. The residue wasfurther separated and purified by silica gel column chromatography (developing agent: system B) to obtainN-(5-(5-amino-4-(1-(phenylsulfonyl)-1H-indole-2-carbonyl)-1H-pyrazol-1-yl)-1H-benzo[d]imida zol-2-yl) acetamide 3e(134mg, brown solid), yield: 13.8%.MS m / z (ESI): 539.8 [M + 1]
1265231-91-1, The synthetic route of 1265231-91-1 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; Zhejiang Hisun Pharmaceutical Co., Ltd; CHEN, Lei; GUAN, Dongliang; BAI, Hua; YAN, Xing; MIAO, Shuai; ZHU, Songsong; (54 pag.)EP3339305; (2018); A1;,
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