Computed Properties of C19H18N2O2. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: Bis((S)-4-phenyl-4,5-dihydrooxazol-2-yl)methane, is researched, Molecular C19H18N2O2, CAS is 132098-59-0, about Enantiotopic Differentiation of pro-R or pro-S Chlorides in (Dichloromethyl)borates by Chiral Lewis Acids: Enantioselective Synthesis of (α-Chloroalkyl)boronates. Author is Jadhav, Prabhakar K.; Man, Hon-Wah.
The 1,2-migration reaction of an alkyl group in borate complexes, I (e.g. R = Bu), derived from dichloromethyl pinacol boronates and alkyllithium was catalyzed by chiral Lewis acids capable of enantiotopic differentiation of Pro (R) or Pro (S) chloride groups on an sp3 C center. It takes place with an enantiomeric ratio of 94:6 to provide α-chloroalkylboronates, II, in 70-75% chem. yields. Chiral Lewis acids examined in this study were prepared in situ from ZnEt2, Yb(OTf)3, Cu(OTf)2, Zn(OTf)2 or Lu(OTf)3 and chiral ligands including amino alcs. and bisoxazolines. Highest enantioselectivity (88% ee) was observed with the chiral Lewis acid derived from Yb(OTf)3 and bisoxazoline III. This is the 1st example of a chiral Lewis acid catalyzed enantioselective 1,2-migration reaction of dichloromethylborate complexes.
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