1477-49-2, 3-Indoleglyoxylic Acid is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
9.2 6-(1H-indol-3-yl)-3-(3-piperidin-1-yl-propylamino)-4H-1,2,4-triazin-5-one A solution of 0.55 g of (1H-indol-3-yl)-oxo-acetic acid and 1.04 g of N-(3-piperidin-1-yl-propyl)-hydrazinecarboximidamide hydroiodide, prepared in stage 9.1, in 3.5 cm3 of water is placed in a reactor. After sealing the tube, the mixture is submitted to discontinuous microwave irradiation for 10 min so that the temperature of the mixture is maintained at 140 C. Then cool the reaction mixture to a temperature close to 20 C., add ethanol and evaporate to dryness under reduced pressure (2.7 kPa) to give a residue which is purified by flash chromatography on silica under argon pressure (50 kPa) [eluent: dichloromethane/methanol/ammonia 32% (90/10/1 by volume)]. After concentrating the fractions under reduced pressure (2.7 kPa), we get 35 mg of 6-(1H-indol-3-yl)-3-(3-piperidin-1-yl-propylamino)-4H-1,2,4-triazin-5-one in the form of a solid. Mass spectrum (ES): m/z=353 (MH+, base peak). 1H-NMR spectrum (300 MHz)-delta in ppm-in DMSO-d6: From 1.15 to 1.85 (m spread-out, 6H); 1.95 (m, 2H); from 2.80 to 3.55 (m spread-out, 8H); from 7.05 to 7.22 (m, 3H); 7.47 (d broad, J=8.0 Hz, 1H); 8.31 (d broad, J=8.0 Hz, 1H); 8.62 (d, J=2.5 Hz, 1H); from 8.95 to 9.15 (m spread-out, 1H); 11.45 (m broad, 1H); 12.3 (m spread-out, 1H)., 1477-49-2
1477-49-2 3-Indoleglyoxylic Acid 73863, aindole-building-block compound, is more and more widely used in various fields.
Reference£º
Patent; AVENTIS PHARMA S.A.; US2008/96891; (2008); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles