162100-95-0, 6-Fluoro-5-methyl-1H-indole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Diethylaluminium chloride 1M in hexane (15 mL, 15.1 mmol) was added dropwise at 000 to a solution of 6-fluoro-5-methyl-1 H-indole [CAS 162100-95-0] (1 .5 g, 10.6mmol) in CH2CI2 (30 mL). After 30 mm at 0C, 2-(4-fluoro-2-methoxyphenyl)acetyl chloride Ia? (3.05 g, 15.1 mmol, synthesis: see Example 1) in CH2CI2 (20 mL) was added slowly at 0C. The reaction was stirred at 0C for 3 h and then at room temperature for 1 h. Ice-water was added. The precipitate was filtered off, washed with water and dried under vacuum to afford 2-(4-fluoro-2-methoxyphenyl)-1 -(6-fluoro-5-methyl-1 H-indol-3-yl)ethanone 3a (2.27 g).
162100-95-0, 162100-95-0 6-Fluoro-5-methyl-1H-indole 2774611, aindole-building-block compound, is more and more widely used in various fields.
Reference：
Patent; JANSSEN PHARMACEUTICALS, INC.; KATHOLIEKE UNIVERSITEIT LEUVEN; BARDIOT, Dorothee Alice Marie-Eve; BONFANTI, Jean-Francois; COESEMANS, Erwin; KESTELEYN, Bart Rudolf Romanie; MARCHAND, Arnaud Didier M; RABOISSON, Pierre Jean-Marie Bernard; (96 pag.)WO2017/167952; (2017); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles