16502-01-5, 2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
(B) will be 516 mg intermediate A dissolved in CH2Cl2In, adding 443 mg of benzoyl chloride (BzCl), under the condition in the ice bath, slowly dropping 455 mg triethylamine (Et3N), stirring at room temperature the reaction 2 h, monitoring after the reaction is complete, the reaction system for CH2Cl2(20 ml) dilution, then adding pure water extraction three times, and finally a saturated salt water, extracted into the organic phase collected drying, turns on lathe does, over silica gel column chromatography separation to obtain 671 mg of intermediate B2, column chromatography in eluting agent is PE/EtOAc=2:1, the reaction yield is 81%; product is a white solid at room temperature.
16502-01-5, 16502-01-5 2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indole 107838, aindole-building-block compound, is more and more widely used in various fields.
Reference£º
Patent; Fuzhou University; Chen Haijun; Ye Jinxiang; Wu Jianlei; Lv Tingting; Li Cailong; Gao Yu; (13 pag.)CN106883230; (2017); A;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles