With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.219552-64-4,tert-Butyl 6-nitro-1H-indole-1-carboxylate,as a common compound, the synthetic route is as follows.
Step 2.Synthesis of 6-Amino-2,3-dihdro-indole-1-carboxylic acid t-butyl ester 6-Nitro-indole-1-carboxylic acid t-butyl ester (1 eq) was dissolved in methanol (0.1M), to this solution was added palladium on carbon (0.1 eq) in methanol under nitrogen.A hydrogen atmosphere was then inserted and resulting mixture allowed to stir for 3 hours at room temperature.The reaction mixture was then filtered through celite and solvent removed in vacuo to afford 6-Amino-2,3-dihdro-indole-1-carboxylic acid t-butyl ester as a white solid. MS: MH+235, 219552-64-4
219552-64-4 tert-Butyl 6-nitro-1H-indole-1-carboxylate 22240526, aindole-building-block compound, is more and more widely used in various fields.
Reference：
Patent; Amiri, Payman; Fantl, Wendy; Levine, Barry Haskell; Poon, Daniel J.; Ramurthy, Savithri; Renhowe, Paul A.; Subramanian, Sharadha; Sung, Leonard; US2004/122237; (2004); A1;,
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