2380-86-1, 1H-Indol-6-ol is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To amixture of compound 10 (1.17 g, 8.78mmol) and Cs2CO3, (3.43 g, 10.54 mmol) in MeCN (30 mL)was added benzyl bromide (1.79 g, 10.54 mmol) and stirred at room temperature for6 h. After the reaction was completed, to the reaction mixture was added water,diluted and extracted with EtOAc. The combined organic extracts were washedwith water and brine, dried over anhydrous MgSO4, filtered, andconcentrated under reduced pressure. The residue was purified by silica gelcolumn chromatography (n-hexane:EtOAc = 2:1) to afford 1.41 g (6.32 mmol, 72percent) of the title compound 11 as gray solid; Rf= 0.34 (n-hexane : EtOAc = 2:1); 1H NMR (400MHz, CDCl3) delta 7.85 (NH, br s), 7.29-7.51 (6H, m), 6.96 (1H, d, J?= 2.0Hz), 6.81-6.88 (2H, m), 6.44 (1H, s), 5.03 (2H, s); 13C NMR (100MHz, CDCl3) delta 155.5, 137.5, 136.4, 128.6, 127.9, 127.6, 123.3, 122.4,121.3, 110.7, 102.4, 96.0, 70.7; IR (neat, cm-1) 3384,3030, 2859, 1625, 1455, 1091., 2380-86-1
The synthetic route of 2380-86-1 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Gim, Hyo Jin; Li, Hua; Jeong, Ji Hye; Lee, Su Jeong; Sung, Mi-Kyung; Song, Mi-Young; Park, Byung-Hyun; Oh, Soo Jin; Ryu, Jae-Ha; Jeon, Raok; Bioorganic and Medicinal Chemistry; vol. 23; 13; (2015); p. 3322 – 3336;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles