256935-86-1, 6-Chloro-1H-indole-5-carboxylic acid is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of 6-chloroindole-5-carboxylic acid (3.9 g, 19.8 mmol) and 4-fluorobenzyl-trans-2,5-dimethyl piperazine (4.4 g, 19.8 mmol) in THF was added TBTU (6.4 g, 19.8 mmol), followed by triethylamine (6.1 g, 60 mmol). The reaction mixture was stirred overnight at RT. and then poured into ice water. The mixture was extracted with dichloromethane. The combined organic layer was washed with brine, dried and concentrated. The residue was purified by chromatography on silica gel eluting with EtOAc:hexane(2:3) to give 6.1 g (77%) of the desired product as a white solid. M+H+(400)., 256935-86-1
The synthetic route of 256935-86-1 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Chakravarty, Sarvajit; Dugar, Sundeep; Lu, Qing; Luedtke, Gregory R.; Mavunkel, Babu J.; Perumattam, John J.; Tester, Richland W.; US2004/142940; (2004); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles