Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 2772-45-4, Name is 2,4-Bis(2-phenylpropan-2-yl)phenol, molecular formula is C24H26O. In an article, author is Ahmad, Aamir,once mentioned of 2772-45-4, Category: indole-building-block.
Pentafluorophenyl Substitution of Natural Di(indol-3-yl)methane Strongly Enhances Growth Inhibition and Apoptosis Induction in Various Cancer Cell Lines
Di(indol-3-yl)methane (=3,3-methanediyldi(1H-indole), DIM, 1) is a known weakly antitumoral compound formed by digestion of indole-3-carbinol (=1H-indol-3-ylmethanol), an ingredient of various Brassica vegetables. Out of a series of nine fluoroaryl derivatives of 1, three pentafluorophenyl derivatives 2c, 2h, and 2i were identified that exhibited a two to five times greater anti-proliferative effect and an increased apoptosis induction when compared with 1 in the following carcinoma cell lines: BxPC-3 pancreas, LNCaP prostate, C4-2B prostate, PC3 prostate and the triple-negative MDA-MB-231 breast carcinoma. Compound 2h was particularly efficacious against androgen-refractory C4-2B prostate cancer cells (IC50=6.4m) and 2i against androgen-responsive LNCaP cells (IC50=6.2m). In addition, 2c and 2h exhibited distinct activity in three cancer cell lines resistant to 1.
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Reference:
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles