With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2795-41-7,6-Fluoroindole-3-carboxaldehyde,as a common compound, the synthetic route is as follows.
1.5 g 3-aldehyde-6-fluoroindole (ie intermediate I-1) was dissolved in isopropanol,Add 150 mg palladium on carbon and 3.2 g sodium borohydride,80 C reflux overnight.After TLC showed that the substrate disappeared,Filter to remove palladium carbon,After the filtrate is concentrated,Add water to quench excess sodium borohydride,Ethyl acetate extractionEach time 15ml,Extract 3 times.Organic layers merge,After drying over anhydrous sodium sulfate,Evaporated to drynessSilica gel column chromatography gave Intermediate I-2 (white solid, quantitative yield)., 2795-41-7
The synthetic route of 2795-41-7 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; Chinese Academy Of Sciences Shanghai Pharmaceutical Institute; Hu Youhong; Geng Meiyu; Xing Weiqiang; Ding Jian; Ai Jing; (86 pag.)CN103664895; (2018); B;,
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