With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.31241-19-7,5-Methoxy-2,3,3-trimethyl-3H-indole,as a common compound, the synthetic route is as follows.
Example 1.9 Synthesis of 5-Hydroxy-1,2,3,3-Tetramethyl-3H-Indolium Iodide This compound was prepared by the general synthesis method 1c) from 4.0 g of 5-methoxy-2,3,3-trimethyl-3H-indole, 16 mL of acetic acid and 16 mL of 48% hydrobromic acid solution. Yield (intermediate): 2.45 g of 5-hydroxy-2,3,3-trimethyl-3H-indole (66% of the theoretical). 1.0 g of the intermediate thus obtained was alkylated with 1.66 g of methyl iodide and 10 mL of methanol according to variant 3 under 1b). Yield: 1.36 g of 5-hydroxy-1,2,3,3-tetramethyl-3H-indolium iodide (75% of the theoretical). Melting point: 245-247 C. 1H-NMR (D6-DMSO): delta=1.46 ppm (s, 6H); 2.66 ppm (s, 3H); 3.89 ppm (s, 3H); 6.93 ppm (dd, 3J=9 Hz, 4J=2 Hz, 1H); 7.11 ppm (d, 4J=2 Hz, 1H); 7.67 ppm (d, 3J=9 Hz, 1H); 10.22 ppm (s, exchanges with D2O, 1H). FAB mass spectrum: M+=190.10 (100% rel. intensity), 31241-19-7
31241-19-7 5-Methoxy-2,3,3-trimethyl-3H-indole 11095392, aindole-building-block compound, is more and more widely used in various fields.
Reference：
Patent; Sauter, Guido; Braun, Hans-Juergen; Reichlin, Nadia; US2003/79301; (2003); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles