With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.348640-06-2,4-Bromo-7-azaindole,as a common compound, the synthetic route is as follows.
To a solution of 4-bromo- l77-pyrrolo[2,3-b]pyridine (200 mg, 1.02 mmol) in DMF (3 mL) was added NaH (49 mg, 2.0 mmol, 60% in mineral oil) at 0 C. Then to the mixture was stirred at 0 C for 30 min. And then Mel (290 mg, 2.04 mmol) was added to the above mixture at 0 C, then the mixture was stirred at 25 C for 15.5 h. TLC showed the reaction was completed. The resulting mixture was concentrated under reduced pressure. The residue was poured into water (50 mL) and stirred at 0 C for 30 min. The aqueous phase was extracted with EtOAc (50 mL x3). The combined organic phase was washed with brine (50 mL), dried over Na2S04, filtered and concentrated in vacuum. The residue was purified by Combi Flash (10% EtOAc in pentane) to give 4-bromo- 1 -methyl- 1 //-pyrrolo| 2.3-b Ipyridine (180 mg, yield: 84%) as yellow oil. NMR (400 MHz, CDCb) d 3.89 (3H, s), 6.49 (1H, d, J= 3.6 Hz), 7.20-7.25 (1H, m), 7.26 (1H, d, J= 2.4 Hz), 8.13 (1H, d, J= 5.2 Hz)., 348640-06-2
The synthetic route of 348640-06-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; PETRA PHARMA CORPORATION; KESICKI, Edward A.; RAVI, Kannan Karukurichi; LINDSTROeM, Johan; PERSSON, Lars Boukharta; LIVENDAHL, Madeleine; VIKLUND, Jenny; GINMAN, Tobias; FORSBLOM, Rickard; RAHM, Fredrik; HICKEY, Eugene R.; DAHLGREN, Markus K.; GERASYUTO, Aleksey I.; (478 pag.)WO2019/126733; (2019); A1;,
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