With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.348640-06-2,4-Bromo-7-azaindole,as a common compound, the synthetic route is as follows.
j0695j To a solution of 4-bromo-1H-pyrrolo[2,3-bjpyridine (XCI) (5 g, 25.4 mmol, 1 eq.), DMAP (311 mg, 2.55 mmol, 0.1 eq.) and TEA (5.3 mL, 38 mmol, 3 eq.) in DCM (100 mL) was added Boc2O (7.2 mL, 31 mmol, 1.2 eq.) at 0C. The reaction was warmed to room temperature and stirred for 2 h. Water (100 mL) was added and extracted with DCM (x 2). Removal solvents gave tert-butyl 4-bromo-1H-pyrrolo[2,3-bjpyridine-1-carboxylate (XCII) as a colorless oil (6.95 g, 23.4 mmol, 92.1% yield). ?H NMR (CDC13, 400 MHz) ppm 1.60 (s, 9H), 6.50 (d, J=4Hz, 1H), 7.31 (d,J=5.2Hz, 1H), 7.63 (d,J=4Hz, 1H), 8.23 (d,J=5.2Hz, 1H); ESIMS found for C,2H,3BrN2O2 mlz 297.1 (M+H).
348640-06-2, The synthetic route of 348640-06-2 has been constantly updated, and we look forward to future research findings.
Reference£º
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