With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.387-43-9,4-Fluoroindole,as a common compound, the synthetic route is as follows.
Synthesis of 4-fluoro-1H-indole-3-carbaldehyde (Intermediate-23) To a 25 mL RB flask fitted with magnetic stirrer were added DMF (0.413 g) and POCl3 (0.623 g, 4 mmol) at 0¡ã C. under N2 atmosphere and the resulting mixture was stirred for 30 minutes at same temperature. Then Starting Material-4 (500 mg, 3.7 mmol) in DMF was added to the mixture and stirred at 40¡ã C. for 1 hour. After completion of the reaction the reaction mixture was cooled to 0¡ã C., quenched with NaOH solution and was extracted with ethyl acetate. Organic layers were concentrated to give crude material, which was then purified by silica-gel column chromatography eluting with hexane:EtOAc to give Intermediate-23 (230 mg) as brown material. LC-MS (M+H)+=164.2.
387-43-9, The synthetic route of 387-43-9 has been constantly updated, and we look forward to future research findings.
Reference£º
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