Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, Safety of 4-(1-Hydroxy-2-(methylamino)ethyl)phenol hydrochloride, 5985-28-4, Name is 4-(1-Hydroxy-2-(methylamino)ethyl)phenol hydrochloride, SMILES is OC1=CC=C(C(O)CNC)C=C1.[H]Cl, belongs to indole-building-block compound. In a document, author is Zhao, Yong-Long, introduce the new discover.
Palladium-catalyzed direct C(sp(3))-H arylation of indole-3-ones with aryl halides: a novel and efficient method for the synthesis of nucleophilic 2-monoarylated indole-3-ones
A novel and efficient method for the synthesis of nucleophilic 2-monoarylated indole-3-ones via palladium-catalyzed direct C(sp(3))-H arylation of indole-3-ones with aryl halides has been developed. Various 2-monoarylated indole-3-ones were readily obtained with yields up to 95%. As a class of important nucleophilic intermediates, 2-monoarylated indole-3-ones can be used for the construction of C2-quaternary indolin-3-one skeletons.
A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 5985-28-4. Safety of 4-(1-Hydroxy-2-(methylamino)ethyl)phenol hydrochloride.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles