Recently I am researching about FEEDBACK ACTIVATION; DRUG-RESISTANCE; DERIVATIVES; BREAST, Saw an article supported by the Major science and technology projects of Guangxi Zhuang Autonomous Region [AA17204090]; Wenzhou science and technology project [Y20170280]; Medical Scientific Research Fund of Zhejiang Province [2019322308]; National Natural Science Funding of ChinaNational Natural Science Foundation of China (NSFC) [21762006]; Specific research project of Guangxi for research bases and talents [2017AD19029]. Published in WILEY in HOBOKEN ,Authors: Xu, LY; Qiu, SS; Yang, LH; Xu, HT; Liu, X; Fan, SQ; Cui, R; Fu, WT; Zhao, CG; Shen, LQ; Wang, LX; Huang, XY. The CAS is 99-93-4. Through research, I have a further understanding and discovery of 4′-Hydroxyacetophenone. Recommanded Product: 99-93-4
Lung cancer is a leading cause of cancer-related death worldwide. Cyanopyridines and aminocyanopyridines with carbon-nitrogen bonds have been proved to exert significant anticancer, antibacterial, and anti-inflammatory effects. In this study, we showed that aminocyanopyridine 3o and 3k displaying potent antitumor activity via inhibiting the signal transducer and activator of transcription 3 (STAT3) pathway. They blocked the constitutive STAT3 phosphorylation in a dose- and time-dependent manner and regulated the transcription of STAT3 target genes encoding apoptosis factors. Most importantly, 3o also inhibited interleukin-6-induced STAT3 activation and nuclear localization. Furthermore, 3o significantly inhibited the tumor growth of H460-derived xenografts. Taken together, these findings suggest that 3o and 3k are promising therapeutic drug candidates for lung cancer by inhibiting persistent STAT3 signaling.
About 4′-Hydroxyacetophenone, If you have any questions, you can contact Xu, LY; Qiu, SS; Yang, LH; Xu, HT; Liu, X; Fan, SQ; Cui, R; Fu, WT; Zhao, CG; Shen, LQ; Wang, LX; Huang, XY or concate me.. Recommanded Product: 99-93-4
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles