An article Synthesis and anticonvulsant evaluation of indoline derivatives of functionalized aryloxadiazole amine and benzothiazole acetamide WOS:000608842900011 published article about DISCOVERY; BINDING in [Nath, Rajarshi; Pathania, Shelly; Grover, Gourav; Akhtar, Md Jawaid] ISF Coll Pharm, Dept Pharmaceut Chem, Ferozpur GT Rd, Moga 142001, Punjab, India; [Yar, M. Shahar] Jamia Hamdard, Sch Pharmaceut Educ & Res, Dept Pharmaceut Chem, New Delhi 110062, India; [Debnath, Biplab] Bharat Technol, Dept Pharm, Howrah 711316, W Bengal, India in 2021, Cited 33. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5. Category: indole-building-block
A series of N-(substituted benzothiazole-2-yl)-2-(2,3 dioxoindolin-1-yl)acetamide (4a-i) and substituted-[3-((5-phenyl-1,3,4-oxadiazole-2-yl)imino)indolene-2-one] (5a-f) were designed, synthesized fulfilling the structural requirement of pharmacophore and evaluated for anticonvulsant activities using maximal electroshock test (MES), subcutaneous pentylenetetrazole (scPTZ) seizures and neurotoxicity by motor impairment model in mice. The most active compound N-(5-chlorobenzo[d]thiazol-2-yl)-2-(2,3-dioxoindolin-1-yl)acetamide (4a) has shown significant anticonvulsant activity against both MES and scPTZ screens and emerged as most effective anticonvulsant compound with median dose of 35.7 mg/kg (MES ED50), 88.15 mg/kg (scPTZ ED50) and toxic dose (TD50) was found to be > 500mg/kg. In silico studies including molecular docking study was carried to establish the molecular interaction of potent compound (4a) in both Na+ channel and GABA(A) receptors. The prediction of pharmacokinetic parameters and distance mapping of compounds were also performed to establish the drug likeness property. (C) 2020 Elsevier B.V. All rights reserved.
Category: indole-building-block. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Nath, R; Yar, MS; Pathania, S; Grover, G; Debnath, B; Akhtar, MJ or concate me.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles