434958-85-7,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.434958-85-7,N-Boc-5-Hydroxyindole,as a common compound, the synthetic route is as follows.
2 g (8.6 mmol) of 5-hydroxy-1-tert-butyl ester-1H-indole (a) was dissolved in 5 ml of DMF.3.56 g (25.8 mmol) of potassium carbonate was added and stirred at room temperature for 10 minutes.Then 14.3 ml (172 mmol) of 1-bromo-2-chloroethane was added.After stirring at 100 C for 10 hours, it was diluted with water and extracted with DCM.Wash with saturated sodium chloride, dry over anhydrous sodium sulfate, concentrate under reduced pressure, and thenPE/EA=200:1 gave a white solid1.3 g, yield 52%.
As the paragraph descriping shows that 434958-85-7 is playing an increasingly important role.
Reference：
Patent; Tianjin University of Science and Technology; Yu Peng; Guo Na; Lv Hongbin; Fu Ying; Teng Yuou; Wang Dong; (32 pag.)CN110229091; (2019); A;,
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