With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4837-90-5,4-Methoxy-1H-indole,as a common compound, the synthetic route is as follows.
A. 1-Benzyl-4-methoxyindole NaH (7.7 g, 191.7 mmol) was added portionwise to a 0 C solution of 4-methoxyindole (21.7 g, 147 mmol) in 750 mL of anhydrous DMF. After 15 min, the slurry was treated with benzyl bromide (17.5 mL, 147 mmol). The reaction mixture was allowed to warm to ambient temperature and stir overnight. The reaction mixture was poured into 1 L of H2O. The layers were separated, and the aqueous phase was extracted with EtOAc (2 X 200 mL). The combined organic layers were washed with H2O (4 x 500 mL), dried over Na2SO4, filtered and concentrated in vacuo.The crude residue was purified by flash chromatography (SiO2; hexanes) to give 32.9 g (138.6 mmol; 94%) of the title compound as a white solid. Electrospray MS 238 (M+1);
4837-90-5, As the paragraph descriping shows that 4837-90-5 is playing an increasingly important role.
Reference£º
Patent; ELI LILLY AND COMPANY; EP950661; (1999); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles