51417-51-7, 7-Bromoindole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Anaerobic conditions,Cooled to 0 C with ice brine,Anhydrous DMF (2.5 g, 34 mmol) was taken in a 100 mL round bottom flask,P0C13 (1.4 g, 8.5 mmol) was added dropwise slowly,After about 10 minutes,0 C to continue the reaction for 30 minutes,Then 7-bromoindole (1.lg, 5.7mmol) was dissolved in 10 mL of DMF and slowly added dropwise to the reaction flask,After about 30 minutes at 0 C,Slowly rose to room temperature,The reaction was carried out for 5 hours,After TLC detection reaction was complete,The first reaction solution was added with saturated NaC03 solution,Adjusted to PH alkaline,While a large number of white solids appear,filter,The filter cake was washed 3 times with 100 mL of water,Dried to a yield of 1.2 g,Yield 94%.
51417-51-7 7-Bromoindole 2757020, aindole-building-block compound, is more and more widely used in various.
Reference£º
Patent; Tianjin University of Science & Technology; YU, PENG; WANG, YIQIAN; JIA, HAIYONG; WEN, SHAOPENG; LYU, LEI; GUO, NA; HAN, KAILIN; CHU, JIE; WANG, TIANJIAO; (13 pag.)CN103864779; (2016); B;,
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